NEWS
AND CLINICAL TRIALS
All studies will be
conducted in Los Angeles, CA
1) NORMAL VOLUNTEERS
AGES 18-55
Normal volunteers of both genders, ages 18-55, to undergo blood
testing, brain SPECT scans and blood pressure measurements. Applicants
must be healthy and off medications. Volunteers will be compensated.
Please call Dr. Friedman or Dr. Zuckerbraun at 323-563-9385 or
email study@goodhormonehealth.com
for more information or to enroll.
2) WOMEN WITH
PITUITARY PROBLEMS WANTED FOR A TESTOSTERONE STUDY
Purpose:
Testosterone is the principal male sex hormone but is also present
in smaller amounts and may be important in women. Among its
likely actions in women are the building of bone and muscle
mass, increase in interest in sex (libido) and effects on the
mood. The role of testosterone replacement in women with low
testosterone levels is currently being studied. In this study,
you will be given an experimental preparation of a testosterone
gel which will be applied on the skin of your outer thigh for
seven days. It is anticipated that this experimental gel application
will produce levels of the drug in the normal range for women.
A further aim of this study is to assess whether female patients
with dysfunction of the pituitary gland have abnormalities in
body composition, muscle strength, thinking and sexual function.
Criteria
for subjects:
-
Women
ages 18 to 55.
-
Hypopituitarism
with documented central adrenal and gonadal deficiencies,
on conjugated equine estrogen replacement
-
Serum
testosterone level of < 20 ng/dl or free testosterone <1.5
pg/ml (can be tested at study site)
-
Written
informed consent
-
No
other significant medical condition
-
Patients
must discontinue their current testosterone replacement
Number of patients-80
Location: King/Drew Medical Center in Willowbrook and UCLA in
West Los Angeles.
Patient Compensation: $800
For more information
or subject referrals contact:
Please call Dr. Friedman or Dr. Zuckerbraun at 323-563-9385
or email study@goodhormonehealth.com
for more information or to enroll.
We have an additional site at OHSU in Portland. Contact Dr. Cook at cookd@ohsu.edu or (503) 494-9000,Extension 1977 for more information.
3) WOMEN WITH PITUITARY
PROBLEMS
Women with pituitary problems, Ages 18-55, to undergo baseline
studies to evaluate consequences of low testosterone and to receive
testosterone replacement for 1 week. Volunteers will be compensated.
Please call Dr. Friedman or Dr. Zuckerbraun at 323-563-9385 or
email study@goodhormonehealth.com
for more information or to enroll.
4) NORMAL FEMALE
VOLUNTEERS
Normal female volunteers, ages 18-55, to undergo blood testing,
muscle, cognitive and sexual function testing. Applicants must
be healthy and off medications. Volunteers will be compensated.
Please call Dr. Friedman or Dr. Zuckerbraun at 323-563-9385 or
email study@goodhormonehealth.com
for more information or to enroll.
5) SUBCLINICAL HYPOTHYROIDISM
Subjects with subclinical hypothyroidism (TSH between 4 and 10
uU/mL and normal T4), ages 18-65, to undergo hormonal, exercise
and quality of life testing. Subjects will then receive either
low dose L-thyroxine, full-dose L-thyroxine or placebo for 6 months.
Volunteers will be compensated. Please contact
Dr. Sahasranam at premsahasranam@yahoo.com -phone number 323-563-9353 for more information or to enroll.
6) A STUDY TO SEE
IF LOWERING INSULIN LEVELS OR MAKING INSULIN WORK BETTER IMPROVES
MILD HYPERTENSION
Distinguishing the Roles of Hyperinsulinemia and Insulin Resistance
in the Pathogenesis of Hypertension
Synopsis: High
blood pressure and blood sugar problems often go together, and
having blood sugar problems may raise a person's blood pressure.
Why this happens is not well understood. This study will test
whether it is the blood sugar problem itself that raises blood
pressure, or rather the high levels of insulin in a person with
blood sugar problems that raises blood pressure. This will be
done by treating people who have mild high blood pressure with
either diazoxide (Proglycem) which lowers insulin levels, or rosiglitazone
(Avandia) which improves the body's handling of sugar, and to
see which of these lowers blood pressure more. This study will
also test the effects of these drugs on your body's handling of
sugars.
Study Design:
Randomized, double-blind, placebo-controlled trial using 2 months
of treatment with either diazoxide, rosiglitazone, or placebo.
Eligibility:
-
Age
over 18
-
Newly-diagnosed
mild high blood pressure, between 140-159 mm Hg over 90-99 mm
Hg (we can test you for this)
-
No
history of diabetes or impaired glucose tolerance (we can test
you for this)
-
No
history of serious heart, liver, or kidney problems
-
Women
of childbearing age must use contraception to avoid pregnancy
during the study
For more information
contact Dr. Stan Hsia,
323-357-3633
7)
DO YOU HAVE TURNER SYNDROME?
If you are 16 years
of age and older, we are inviting you to participate in a study
that uses testosterone (male hormone) to see if there is going
to be improvement in your psychological skills, sexual function
and muscle mass.
Monetary compensation
is provided
Contact Dr. Salehian
(310) 668-6057
8)
DO YOU KNOW THAT OBESITY CAN HARM YOU BY INCREASING THE RISK OF
DEVELOPING DIABETES, HYPERTENSION, AND HEART DISEASE?
A
clinical research is ongoing at king/drew medical center for metabolic
treatment of obesity to decrease harmful risks associated with
obesity
(Weight loss is not anticipated)
If you are interested call: (310) 668-6057,and ask for Dr. Salehian
Monetary compensation is provided
9)
HEALTHY POSTMENOPAUSAL WOMEN NEEDED
Women over the age of 51 and who have stopped menstruating for
one year are invited to participate in a research study on testosterone.
Financial compensation is provided.
For more information please call: 323-357-3492
10)
MEN WITH KIDNEY FAILURE NEEDED FOR RESEARCH STUDY
Men with kidney failure
on dialysis, 18-75 years of age are invited to participate in
a research study on testosterone and its effects on muscle strength
and physical function. Financial Compensation is Provided.
For more information please call: 323-357-3492
11) HEALTHY ELDERLY MEN NEEDED FOR RESEARCH
STUDY
Healthy men ages 65-90 are invited to participate in a research
study to test the effects of testosterone and growth hormone on
muscle mass, strength and everyday function. Financial compensation
is provided.
For more information
please call: 323-563-9322
12)
OVERWEIGHT MEN NEEDED FOR RESEARCH STUDY
Healthy men who are overweight (ages 21-50) are invited to participate
in a research study to test the effects of testosterone on fat
mass and risk for diabetes. Financial compensation is provided.
For more information
please call: 323-563-9322
13)
RECRUITING PATIENTS WITH CHRONIC FATIGUE SYNDROME(CHRONIC FATIGUE AND IMMUNE DYSFUNCTION SYNDROME) FOR CLINICAL STUDY
Purpose: The purpose of this study is to determine whether chronic fatigue syndrome (CFS) is due to inadequate blood flow to the brain and to test a medication which may help increase blood flow to the brain and improve the symptoms of CFS. We propose that in a subset of patients with CFS, there is inadequate blood flow to the brain, resulting in some of the symptoms of chronic fatigue syndrome. To determine if this is the case, you will have brain scans called SPECT scans, which measure blood flow to your brain. We will also do a test to measure your blood pressure in different positions, called a tilt-table test.
You will then receive drug or placebo (sugar-pill) in a blinded (such that neither you nor your doctors know if you are taking drug or placebo) manner as a possible treatment for CFS. We will test the idea that this drug will increase blood flow to the brain and improve symptoms related to CFS. We will also test if this drug improves your thinking process. It is expected that these tests will help allow doctors to understand what causes chronic fatigue syndrome.
Criteria for subjects:
A. Research subjects meeting the CDC definition of CFS.
B. All races, ethnicities, socio-economic status (SES), and gender
C. Age 18-50.
D. Able to provide informed consent.
E. Willingness to be off all medicines effecting the brain and supplements for 3 weeks prior to the study.
F. Research subjects with psychiatric disorders or concurrent fibromyalgia will be included, if they could be off their medications
Location: King/Drew Medical Center in Willowbrook and Harbor-UCLA in Torrance. Both of these locations are in Los Angeles, CA.
Enrollment Period: on going
Patient Compensation: $200
For more information or subject referrals contact:
Erik Zuckerbraun, M.D.
Telephone (323) 563-9385
Email: study@goodhormonehealth.com
Fax: (323) 563-9324
Charles R. Drew University
of Medicine and Sciences
1731 E. 120th St., Los Angeles CA 90059
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